Coronary Artery Disease in Granulomatosis with Polyangiitis: a Review

Abstract Granulomatosis with polyangiitis is an immunologically mediated small to medium vessel vasculitis associated the formation of antineutrophil cytoplasmic antibodies. Advances in immunosuppressive therapy have expanded patients’ life expectancy recent decades and required expansion clinical attention include management chronic disease manifestations long-term comorbidities. Though heart coronary arteries specifically are typically not primarily affected GPA, studies shown that patients at increased risk cardiovascular thromboembolic events. In many patients, metabolic factors promoting atherosclerotic plaques sufficiently controlled or screened for potentially exacerbated by undesired treatment effects. This review aims provide physicians overview current literature on epidemiology, pathophysiology prevention artery context granulomatosis help identify lower events this high-risk population.